Drug Discovery Research Screening Libraries
Apexbio Technology LLC DiscoveryProbe™ Inhibitor Library, 100uL/well(10 mM solution),96 Well Racks With Screw Cap
A unique collection of 2525 inhibitors for high throughput screening (HTS) and high content screening (HCS). Other sizes are available. Please inqury us for quote.
Apexbio Technology LLC DiscoveryProbe™ Anti-infection Compound Library, 100uL/well(10 mM solution),96 Well Racks With Screw Cap
A unique collection of 367 anti-infection small molecules for anti-infection reasearch. Other sizes are available. Please inqury us for quote.
Apexbio Technology LLC DiscoveryProbe™ Stem Cell Compound Library, 250uL/well(10 mM solution), 96 Well Racks With Screw Cap
A unique collection of 169 stem cell-related compounds for stem cell research. Other sizes are available. Please inqury us for quote.
AdipoGen Helvolic acid
Chemical. CAS 29400-42-8. Formula C33H44O8. MW 568.7. Isolated from Aspergillus fumigatus Strain WDMH-35. Steroidal triterpene. Antibiotic. Antibacterial. Shows broad activity against Gram positive and negative bacteria. Mycotoxin. Antifungal. Antitumor agent. Cytotoxic against different human cancer cells. Antituberculosis agent. Oxidized LDL uptake inhibitor. Phytotoxin. Inhibitor of the protein biosynthesis through archeal elongation factor 2 EF-2.
AdipoGen Dimethyl fumarate
Chemical. CAS 624-49-7. Formula C6H8O4. MW 144.1. Immunomodulatory and anti-inflammatory agent used in patients with relapsing-remitting multiple sclerosis MS and psoriasis. Causes an immune switch characterized by induction of anti-inflammatory/regulatory innate and adaptive immune cell populations such as regulatory T cells Tregs and inhibition or apoptosis of pro-inflammatory cells, such as T helper 1 Th1 and Th17 subsets. Blocks immune cell activation through inhibition of glycolysis via post-transcriptional modification succination of glyceraldehyde 3-phosphate dehydrogenase GAPDH in vitro and in vivo and is therefore a useful agent for immunometabolism research. GAPDH catalyzes the conversion of glyceraldehyde 3-phosphate to 1,3-bisphosphoglycerate during glycolysis, an essential metabolic pathway where glucose is converted to pyruvate, to fuel the TCA cycle and oxidative phosphorylation OXPHOS for the production of adenosine triphosphate ATP as an energy source.
AdipoGen Glyburide USP
Chemical. CAS 10238-21-8. Formula C23H28ClN3O5S. MW 494. Antidiabetic compound. Binds to and activates the ATP-sensitive potassium channels KATP inhibitory regulatory subunit sulfonylurea receptor 1 SUR1. Causes cell membrane depolarization and opening of voltage-dependent calcium channel. Increases intracellular calcium and stimulates insulin secretion in beta cells NLRP3 inflammasome inhibitor. Broad-spectrum ATP-binding cassette ABC transporter inhibitor. Shown to have anti-leishmanial activity. Potential inhibitor of collagenases.
AdipoGen Mubritinib
Chemical. CAS 366017-09-6. Formula C25H23F3N4O2. MW 468.5. Mubritinib TAK-165 is a selective inhibitor of the human epidermal growth factor receptor 2 EGFR2 HER2, inhibiting HER2 phosphorylation with an IC50 value of 6nM. It is 4000-fold selective over EGFR, FGFR, PDGFR, JAK1, Src and Blk IC50 > 25μM. Mubritinib inhibits the proliferation of breast, bladder, kidney and prostate cancer cells in vitro and in vivo. Mubritinib was shown to inhibit autophagy in a HER2-independent manner in cancer cells. Recently shown to be a mitochondrial electron transport chain complex I NADH-CoQ reductase inhibitor. Mubritinib functions through ubiquinone-dependent inhibition of electron transport chain ETC complex I activity and consequently oxidative phosphorylation OXPHOS. This agent could be useful for immunometabolism research. Inhibition of electron transport chain in mitochondria leads to blocking of the transfer of electrons from iron-sulfur centers in complex I to ubiquinone.
AdipoGen D-Mannoheptulose
Chemical. CAS 3615-44-9. Formula C7H14O7. MW 210.2. . Naturally occurring heptose in avocado fruit. Hexokinase HK and glucokinase inhibitor in diverse organisms by competing with D-glucose. Useful agent for immunometabolism research. Blocks glucose phosphorylation by blocking hexokinase. Prevents the conversion of glucose to glucose-6-phosphate that can mediate the activation of the carbohydrate response element binding protein and consequently inhibiting the rate limiting step of glycolysis. Blocks glucose oxidation and glucose-mediated insulin release in pancreatic islet cells.
AdipoGen Glyburide USP
Chemical. CAS 10238-21-8. Formula C23H28ClN3O5S. MW 494. Antidiabetic compound. Binds to and activates the ATP-sensitive potassium channels KATP inhibitory regulatory subunit sulfonylurea receptor 1 SUR1. Causes cell membrane depolarization and opening of voltage-dependent calcium channel. Increases intracellular calcium and stimulates insulin secretion in beta cells NLRP3 inflammasome inhibitor. Broad-spectrum ATP-binding cassette ABC transporter inhibitor. Shown to have anti-leishmanial activity. Potential inhibitor of collagenases.
AdipoGen OCH
Chemical. CAS 383187-82-4. Formula C39H77NO9. MW 704. Truncated analog of alpha-GalCer. iNKT cell glycolipid agonist. Immunosuppressive. Th2 polarizing. Stimulation of NKT with OCH results in release of primarily Th2 cytokine compared to stimulation with alpha-GalCer, which results in release of a mixture of Th1 and Th2 cytokines. Induces stronger interleukin-4 IL-4 secretion and weaker interferon-gamma IFN-gamma secretion than alpha-GalCer both in vitro and in vivo. Inducer of interleukin-10 IL-10 and suppressor of diabetes. Shown to prevent experimental autoimmune encephalomyelitis EAE in mice, an animal model of multiple sclerosis. Has beneficial effects on type I diabetes in NOD mice. Suppressor of collagen-induced arthritis. Might be useful for immunotherapy of transplant rejection.
AdipoGen CL 316 243
Chemical. CAS 138908-40-4. Formula C20H18ClNO7 . 2Na. MW 419.8 . 46.0. Potent and selective beta3-adrenoceptor agonist EC50=3nM that is >10,000-fold selective over beta1 and beta2. Antidiabetic and antiobesity agent. Causes a rapid decrease in blood glucose level in mice. Increases brown adipose tissue thermogenesis. Induces functionally active mitochondrial uncoupling protein UCP in white fat. Restores the expression of down-regulated fatty acid oxidation genes in type 2 diabetic mice.
AdipoGen AP-III-a4 HCl
Chemical. CAS 1177827-73-4 free base. Formula C31H43FN8O3 . HCl. MW 594.7 . 36.5. . Cell-permeable first non-substrate analog enolase inhibitor IC50=0.576µM. A recent study suggested no directly blocking of enolase activity in vitro and a indirect mechanism. Useful agent for immunometabolism research. The glycolysis enzymes enolase is known to have additional, non-glycolytic roles in cellular physiology, which has been termed moonlighting. Anticancer agent. Inhibits cancer cell metastasis in a zebrafish cancer cell xenograft model. Induces cell death under hypoxia and inhibits cancer cell migration and invasion by down-regulation of AKT and Bcl-xL expression. Antidiabetic agent. Reduced hyperglycemia and hyperlipidemia in mice. Reduced blood glucose, LDL cholesterol and enolase activity in T2DM mice. Had beneficial effects on lipid homeostasis, fibrosis, inflammatory markers, nephrotoxicity and cardiac hypertrophy.
AdipoGen Rosiglitazone maleate
Chemical. CAS 155141-29-0. Formula C18H19N3O3S . C4H4O4. MW 357.4 . 116.1. Same activities as rosaglitazone Prod. No. AG-CR1-3570 but different formulation. Antidiabetic, hypoglycemic agent. Potent and selective peroxisome proliferator-activated receptor gamma PPAR-gamma agonist. Potent insulin sensitizing agent binding to the PPAR receptors in fat cells and making the cells more responsive to insulin. Ameliorates insulin resistance. Improves blood pressure and vascular function. Enhances proliferation of endogenous neural progenitor cells NPCs. Anti-inflammatory compound. Has controversial therapeutic effects on the cardiovascular system. Promotes adipocyte differentiation of mesenchymal stem cells MSCs.
AdipoGen AP-III-a4 HCl
Chemical. CAS 1177827-73-4 free base. Formula C31H43FN8O3 . HCl. MW 594.7 . 36.5. . Cell-permeable first non-substrate analog enolase inhibitor IC50=0.576µM. A recent study suggested no directly blocking of enolase activity in vitro and a indirect mechanism. Useful agent for immunometabolism research. The glycolysis enzymes enolase is known to have additional, non-glycolytic roles in cellular physiology, which has been termed moonlighting. Anticancer agent. Inhibits cancer cell metastasis in a zebrafish cancer cell xenograft model. Induces cell death under hypoxia and inhibits cancer cell migration and invasion by down-regulation of AKT and Bcl-xL expression. Antidiabetic agent. Reduced hyperglycemia and hyperlipidemia in mice. Reduced blood glucose, LDL cholesterol and enolase activity in T2DM mice. Had beneficial effects on lipid homeostasis, fibrosis, inflammatory markers, nephrotoxicity and cardiac hypertrophy.
AdipoGen SB415286
Chemical. CAS 264218-23-7. Formula C16H10ClN3O5. MW 359.7. Synthetic. Potent and selective cell permeable, ATP-competitive inhibitor of GSK3alpha with an IC50 value of 78nM and similar potency for GSK3beta. DYRK1A inhibitor IC50=0.9µM. Stimulates glycogen synthesis in liver cells and induces beta-catenin-dependent gene transcription. Acts as neuroprotectant and prevents neuronal cell death induced by PI3-kinase pathway. Anticancer agent with antiproliferative activity. Glycogen synthase kinase 3 GSK3 is a serine/threonine protein kinase that is inhibited by an assortment of extracellular stimuli such as insulin, growth factors, cell specification factors and cell adhesion. Its activity regulates many cell functions including the control of cell division, apoptosis and inflammation.